Qualitative and Quantitative Analysis of 70% Ethanol Extract from Ruta angustifolia for Developing Anti-Hepatitis C Agents

Background: Medicinal plants are potential sources for drug candidates. It possesses with various metabolites which have many pharmacology effects. Ruta angustifolia is one of medicinal that has been used traditionally liver disease. Previous study it demonstrated to inhibit hepatitis C virus under in vitro cell culture. decreased protein NS3 level and gave synergistic effect combination simeprevir telaprevir. This plant provides a prospective candidate develop as anti-HCV Objective: evaluates the phytochemistry screening qualitative assay determine concentration rutin marker compound developing R. extract agent. Materials Methods: leaves were extracted 70% ethanol. Extract analysis their activity by culture cells Huh7it. The was TLC densitometry. Results: ethanol dan exhibit activities IC50 value 2.9 ± 0.8 ?g/ml 28.1 5.6 ?g/ml, respectively. Screening contain flavonoid, terpenoid, alkaloid polyphenols. densitometry yield 0.06 %. Conclusion: activity. may provide good agents.